AC C00011
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ID C2H2$STAT_002
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DT 01.03.2002 (updated); oke.
CO Copyright (C), Biobase GmbH.
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GE G000709; RAT$BCAS; beta-casein; rat, Rattus norvegicus.
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SQ GAAACCATTTtctaatcatgtgaacTTCTTGGAATT
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PS -119 to -84
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DR EMBL: M10936; RNCASB1; 662.
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BS -119 to -110; YY1.
BS -94 to -84; MGF family member.
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TY antagonism
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CL tissue-restricted/ubiquitous.
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CC MGF activates b-casein expression in mammary gland-cells during late
CC pregnancy and lactation. YY1 binds b-casein milk box with relatively low
CC affinity compared with YY1 binding site in the chicken a-actin promoter.
CC MGF act cooperatively with other unidentified protein to activate b-casein
CC expression by formation of LAC, lactation-associated complex. It is likely
CC that unidentified protein binds between -110 to -94. MGF family member was
CC later identified with STA5 (see also C00298).
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EV ev00027
EX Site-directed mutagenesis and study of promoter activity
CN Functional antagonism between sites
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EV ev00028
EX Co-transfection experiment
CN Functional antagonism between factors
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EV ev00029
CN Competition between TFs for overlapping binding sites
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RN [1]
RX MEDLINE; 94158847.
RA Raught B., Khursheed B., Kazansky A., Rosen J.
RT YY1 represses beta-casein gene expression by preventing the formation of a
RT lactation-associated complex
RL Mol. Cell. Biol. 14:1752-1763 (1994).
RN [2]
RA Meier V. S., Groner B.
RT The nuclear factor YY1 participates in repression of the beta-casein gene
RT promoter in mammary epithelial cells and is counteracted by mammary gland
RT factor during lactogeneic hormone induction.
RL Mol. Cell. Biol. 14:128-137 (1994).
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