Transcription Factor Classification
Last modified 2002-10-01

1 Superclass: Basic Domains

2 Superclass: Zinc-coordinating DNA-binding domains

    2.1 Class: Cys4 zinc finger of nuclear receptor type.
      2.1.1 Family: Steroid hormone receptors
        2.1.1.1 Subfamily: Corticoid receptors
          2.1.1.1.1 GR (rat); GR (mouse); GR (human).
            2.1.1.1.1.1 GR a
            2.1.1.1.1.2 GR b
          2.1.1.1.2 MR (rat); MR (human).
        2.1.1.2 Subfamily: Progesterone receptor
          2.1.1.2.1 PR (human); PR (rabbit); PR (chick).
            2.1.1.2.1.1 PR-B
            2.1.1.2.1.2 PR-A
        2.1.1.3 Subfamily: Androgen receptor
          2.1.1.3.1 AR (human); AR (mouse); AR (rat).
            2.1.1.3.1.1 AR-A
            2.1.1.3.1.2 AR-B
        2.1.1.4 Subfamily: Estrogen receptor
          2.1.1.4.1 ER (rat); ER (mouse); ER (human); ER (clawed frog); ER (chick).
            2.1.1.4.1.1 ER (h) / ER-A (X)
            2.1.1.4.1.2 ER (482 AA) (h)
            2.1.1.4.1.3 ER-B (X)
      2.1.2 Family: Thyroid hormone receptor-like factors
    2.2 Class: diverse Cys4 zinc fingers.
      2.2.1 Family: GATA-Factors
        2.2.1.1 Subfamily: vertebral GATA-Factors 2.2.1.2 Subfamily: fungal metabolic regulators
          2.2.1.2.1 AREA / NIT-2 (Neurospora crassa).
          2.2.1.2.2 GLN3
          2.2.1.2.3 UGA 43
          2.2.1.2.4 NTL 1
      2.2.2 Family: Trithorax
          2.2.2.0.1 Ttx (fruit fly).
          2.2.2.0.2 Hrx
      2.2.0 Family: Other factors
          2.2.0.0.1 BUF2
    2.3 Class: Cys2His2 zinc finger domain.
      2.3.1 Family: Ubiquitous factors
          2.3.1.0.1 TFIIIA
          2.3.1.0.2 Sp1 (mouse); Sp1 (rat); Sp1 (human).
          2.3.1.0.3 Sp3
          2.3.1.0.4 Sp4
          2.3.1.0.5 YY1 (human).
      2.3.2 Family: Developmental / cell cycle regulators
        2.3.2.1 Subfamily: Egr/Krox 2.3.2.2 Subfamily: Krueppel-like
          2.3.2.2.1 Krueppel (fruit fly).
          2.3.2.2.2 Hunchback (fruit fly).
          2.3.2.2.3 Glass (fruit fly).
          2.3.2.2.4 Odd-skipped (fruit fly).
          2.3.2.2.5 Ovo (fruit fly).
          2.3.2.2.6 Snail (fruit fly).
          2.3.2.2.7 CF2
            2.3.2.2.7.1 CF2-I (fruit fly).
            2.3.2.2.7.2 CF2-II (fruit fly).
            2.3.2.2.7.3 CF2-III (fruit fly).
          2.3.2.2.8 Evi-1 (mouse).
          2.3.2.2.9 Ikaros (mouse).
          2.3.2.2.10 MZF-1 (human).
          2.3.2.2.11 Sdc-1 (Caenorhabditis elegans).
          2.3.2.2.12 NRSF
            2.3.2.2.12.1 NRSF form 1
            2.3.2.2.12.2 NRSF form 2
          2.3.2.2.13 Gfi-1
        2.3.2.3 Subfamily: GLI-like
          2.3.2.3.1 GLI (human).
          2.3.2.3.2 GLI3 (human).
          2.3.2.3.3 WT1
            2.3.2.3.3.1 WT1 +KTS (human).
            2.3.2.3.3.2 WT1 -KTS (human).
            2.3.2.3.3.3 WT1 I
            2.3.2.3.3.4 WT1 I -KTS
            2.3.2.3.3.5 WT1-del2
            2.3.2.3.3.6 WT1-del2 I
          2.3.2.3.4 Tra-1 2.3.2.3.5 RME1 (yeast).
          2.3.2.3.6 BrlA (Aspergillus nidulans).
        2.3.2.0 Subfamily: Others
      2.3.3 Family: Metabolic regulators in fungi
          2.3.3.0.1 ACE2 (yeast).
          2.3.3.0.2 ADR1 (yeast).
          2.3.3.0.3 MIG1 (yeast).
          2.3.3.0.4 CreA (Aspergillus nidulans).
          2.3.3.0.5 MSN2 (yeast).
          2.3.3.0.6 MSN4 (yeast).
      2.3.4 Family: Large factors with NF-6B-like binding properties 2.3.5 Family: Viral regulators
          2.3.5.0.1 T-Ag (SV40).
    2.4 Class: Cys6 cysteine-zinc cluster.
      2.4.1 Family: Metabolic regulators in fungi
          2.4.1.0.1 ARG RII (yeast).
          2.4.1.0.2 CAT8
          2.4.1.0.3 GAL4 (yeast).
          2.4.1.0.4 HAP1 (yeast).
          2.4.1.0.5 MAL63 (yeast).
          2.4.1.0.6 LEU3 (yeast).
          2.4.1.0.7 UGA3
          2.4.1.0.8 qa-1F (Neurospora crassa).
          2.4.1.0.9 UME6 (yeast).
          2.4.1.0.10 AmdR (Aspergillus nidulans).
          2.4.1.0.11 PUT3
    2.5 Class: Zinc fingers of alternating composition
      2.5.1 Family: Cx7Hx8Cx4C zinc fingers
          2.5.1.0.1 BAF1 (yeast).
      2.5.2 Family: Cx2Hx4Hx4C zinc fingers
          2.5.2.0.1 Byr3 (fission yeast).

3 Superclass: Helix-turn-helix

    3.1 Class: Homeo domain.
      3.1.1 Family: Homeo domain only
        3.1.1.1 Subfamily: AbdB 3.1.1.2 Subfamily: Antp
          3.1.1.2.1 abd-A (fruit fly).
          3.1.1.2.2 Antp (fruit fly).
            3.1.1.2.2.1
            3.1.1.2.2.2
          3.1.1.2.3 Ceh-15
          3.1.1.2.4 Dfd (fruit fly).
          3.1.1.2.5 Flh (zebra fish); Flh (clawed frog).
          3.1.1.2.6 Ftz (fruit fly).
          3.1.1.2.7 HOXA2 (mouse); HOXA2 (rat); HOXA2 (chick).
          3.1.1.2.8 HOXB2