TRANSFAC® Release 7.0 - Documentation
TRANSFAC® is a database on eukaryotic cis-acting regulatory DNA elements
and trans-acting factors. It covers the whole range from yeast to human.
TRANSFAC® started 1988 with a printed compilation (Nucleic Acids Res. 16:
1879-1902, 1988) and was transferred into computer-readable format in
1990 (BioTechForum - Advances in Molecular Genetics (J. Collins, A.J.
Driesel, eds.) 4:95-108, 1991). The basic structures of Table 1 and 2 of
the compilation were taken as the core of the emergent database. The aim
of the early compilation as well as of the TRANSFAC® database is
||to guide through a meanwhile overwhelming amount of data in a field which is connected
to nearly all areas of modern molecular biology;
||to map the regulatory sites in the individual genes and, ultimately, in the genome(s) as a
||to develop a tool for the identification of regulatory elements in newly unravelled
||to provide a basis for a more comprehensive understanding of how the genome governs
The TRANSFAC® data have been generally extracted from the original
literature, occasionally they have been taken from other compilations
(Faisst and Meyer, Nucleic Acids Res. 20:3-26, 1992; Dhawale and Lande,
Nucleic Acids Res. 21:5537-5546, 1994) which is appropriately indicated.
Thus, the main responsibility for the correctness of the data is up to
the authors, while we have to assume any responsibility for correctly
extracting their publications. In a long term, a direct submission
system should be envisaged similar to that established for depositing
sequence data in the sequence data libraries.