TRANSPATH^® 6.0 Public 2005 provides data about molecules participating in signal transduction pathways and the reactions they are involved in, resulting in a complex network of interconnected signaling components.

TRANSPATH focuses on signaling cascades that change the activities of transcription factors and thus alter the gene expression profile of a given cell.

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PathoDB^® 2.0 Public 2005 is a database on pathologically relevant mutated forms of transcription factors and their binding sites.

It comprises numerous cases of defective transcription factors or mutated transcription factor binding sites, which are known to cause pathological defects.

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S/MARt DB^TM 1.1 Public 2005 presents data on scaffold or matrix attached regions (S/MARs) of eukaryotic genomes, as well as about the proteins that bind to them.

S/MARs organize the chromatin in the form of functionally independent loop domains gained increasing support. Scaffold or Matrix Attached Regions (S/MARs) are genomic DNA sequences through which the chromatin is tightly attached to the proteinaceous scaffold of the nucleus.

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• SbBlast: Search Tool for Sequence Search in the S/MARt Binder Database

TRANSCompel^® 7.0 Public 2005 is a database on composite regulatory elements affecting gene transcription in eukaryotes. Composite regulatory elements consist of two closely situated binding sites for distinct transcription factors, and provide cross-coupling of different signalling pathways.

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• Documentation (About Composite Elements, Fields Description)

Cytomer^® 0.4 Public is a relational database on "gene expression sources" which lists physiological systems,organs and cell types. It differentiates these objects according to the developmental stage. Presently, this module is restricted to human and mouse sources.

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• C. elegans in CYTOMER^®

PathoSign Public is a database which collects information about defective cell signaling molecules causing human diseases. It has been developed by and is maintained in the Department of Bioinformatics, Center of Informatics, Statistics and Epidemiology, Göttingen Medical School, University of Göttingen While constituting a useful data repository in itself, PathoSign is also aimed at being a foundational part of a platform for modeling human disease processes, which is the overarching goal of the department's efforts. Part of this work was funded by the TEMBLOR (EU, contract no. QLRI-CT-2001-00015) and NGFN2 (German Ministry of Education and Research, grant no. 01GR0480) projects.

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